The Saints defense gave up a late 4th quarter touchdown and the Saints fell to the Panthers 17-13.
Brees threw for 281 yards with a touchdown and two interceptions. Brees was pressured all game and sacked six times.
With a win next week over Atlanta, Carolina wins the NFC South.
New Orleans can still win the NFC South with a win over Tampa Bay next week and a Carolina loss to Atlanta.
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